Transcription factors with Perturb-seq knockdown data for LRRC20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:70,116,082–70,116,892 | 266.2 kb | Distal (>10kb) Multiome | 217 | |
| chr10:70,132,124–70,133,061 | 249.9 kb | Distal (>10kb) Multiome | 729 | |
| chr10:70,145,328–70,147,235 | 237.0 kb | Distal (>10kb) Multiome | 1006 | |
| chr10:70,169,902–70,171,034 | 212.0 kb | Distal (>10kb) Multiome | 777 | |
| chr10:70,232,204–70,234,260 | 149.0 kb | Distal (>10kb) Multiome | 949 | |
| chr10:70,379,648–70,379,840 | 2.8 kb | Proximal (<10kb) | 81 | |
| chr10:70,381,835–70,383,091 | 43 bp | At TSS Multiome | 693 | |
| chr10:70,387,327–70,387,544 | 4.7 kb | Proximal (<10kb) | 213 | |
| chr10:70,387,632–70,387,815 | 5.0 kb | Proximal (<10kb) | 251 | |
| chr10:70,403,687–70,404,709 | 21.4 kb | Distal (>10kb) Multiome | 788 | |
| chr10:70,437,649–70,438,147 | 55.3 kb | Distal (>10kb) Multiome | 93 | |
| chr10:70,439,787–70,443,007 | 60.0 kb | Distal (>10kb) Multiome | 501 | |
| chr10:70,455,031–70,455,839 | 72.8 kb | Distal (>10kb) Multiome | 196 | |
| chr10:70,458,264–70,459,984 | 76.0 kb | Distal (>10kb) Multiome | 310 | |
| chr10:70,478,010–70,479,323 | 96.1 kb | Distal (>10kb) Multiome | 492 | |
| chr10:70,672,118–70,672,962 | 289.9 kb | Distal (>10kb) Multiome | 465 |
Genomic view of the LRRC20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.