Involved in negative regulation of fat cell differentiation; positive regulation of osteoblast differentiation; and regulation of gene expression. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:32,971,721–32,972,560 | 205.5 kb | Distal (>10kb) Multiome | 796 | |
| chr19:33,022,514–33,023,071 | 154.8 kb | Distal (>10kb) Multiome | 102 | |
| chr19:33,064,252–33,065,504 | 112.7 kb | Distal (>10kb) Multiome | 603 | |
| chr19:33,080,776–33,081,465 | 96.5 kb | Distal (>10kb) Multiome | 838 | |
| chr19:33,176,278–33,177,966 | 459 bp | At TSS Multiome | 1077 | |
| chr19:33,184,294–33,184,576 | 6.7 kb | Proximal (<10kb) | 299 | |
| chr19:33,193,912–33,194,503 | 16.7 kb | Distal (>10kb) Multiome | 256 | |
| chr19:33,225,334–33,226,211 | 48.1 kb | Distal (>10kb) Multiome | 146 | |
| chr19:33,226,520–33,227,396 | 49.5 kb | Distal (>10kb) Multiome | 219 | |
| chr19:33,301,181–33,303,965 | 125.1 kb | Distal (>10kb) Multiome | 945 | |
| chr19:33,373,183–33,374,325 | 196.0 kb | Distal (>10kb) Multiome | 871 | |
| chr19:33,406,730–33,407,310 | 229.4 kb | Distal (>10kb) Multiome | 393 |
Genomic view of the LRP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.