Predicted to enable nuclear retinoic acid receptor binding activity. Involved in dosage compensation by inactivation of X chromosome. Located in centriolar satellite; chromosome, telomeric region; and nuclear lumen. Implicated in facioscapulohumeral muscular dystrophy 3. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRIF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRIF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRIF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:110,674,115–110,675,737 | 289.0 kb | Distal (>10kb) Multiome | 392 | |
| chr1:110,963,212–110,964,499 | 33 bp | At TSS Multiome | 1038 | |
| chr1:111,139,287–111,140,818 | 176.1 kb | Distal (>10kb) Multiome | 930 | |
| chr1:111,203,689–111,204,663 | 240.4 kb | Distal (>10kb) Multiome | 352 | |
| chr1:111,219,041–111,220,185 | 255.7 kb | Distal (>10kb) Multiome | 219 |
Genomic view of the LRIF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.