Predicted to enable guanylate kinase activity. Predicted to be involved in axoneme assembly and spermatogenesis. Predicted to be located in acrosomal vesicle and manchette. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for LRGUK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRGUK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRGUK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:132,575,506–132,577,965 | 1549.9 kb | Distal (>10kb) Multiome HiCAR | 307 | |
| chr7:132,614,538–132,615,559 | 1512.4 kb | Distal (>10kb) Multiome HiCAR | 182 | |
| chr7:134,126,989–134,127,843 | 9 bp | At TSS Multiome | 460 | |
| chr7:134,140,952–134,141,759 | 14.0 kb | Distal (>10kb) Multiome | 331 | |
| chr7:134,316,231–134,317,622 | 189.6 kb | Distal (>10kb) Multiome | 905 |
Genomic view of the LRGUK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.