Predicted to be involved in regulation of postsynaptic density assembly; regulation of presynapse assembly; and synaptic membrane adhesion. Predicted to be located in plasma membrane. Predicted to be active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for LRFN4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRFN4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRFN4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:66,568,061–66,568,910 | 288.1 kb | Distal (>10kb) Multiome | 392 | |
| chr11:66,592,561–66,593,452 | 263.6 kb | Distal (>10kb) Multiome | 857 | |
| chr11:66,616,078–66,617,408 | 240.1 kb | Distal (>10kb) Multiome | 1011 | |
| chr11:66,637,919–66,639,003 | 218.1 kb | Distal (>10kb) Multiome | 872 | |
| chr11:66,677,182–66,678,796 | 178.7 kb | Distal (>10kb) Multiome | 926 | |
| chr11:66,728,259–66,728,943 | 128.2 kb | Distal (>10kb) Multiome | 275 | |
| chr11:66,744,354–66,745,291 | 111.9 kb | Distal (>10kb) Multiome | 747 | |
| chr11:66,842,896–66,843,952 | 13.2 kb | Distal (>10kb) Multiome HiCAR | 843 | |
| chr11:66,855,758–66,857,980 | 270 bp | At TSS Multiome | 795 | |
| chr11:66,882,995–66,883,462 | 26.6 kb | Distal (>10kb) Multiome | 277 | |
| chr11:66,957,708–66,959,038 | 101.9 kb | Distal (>10kb) Multiome HiCAR | 957 | |
| chr11:67,023,002–67,023,688 | 166.8 kb | Distal (>10kb) Multiome | 243 | |
| chr11:67,056,596–67,057,312 | 200.2 kb | Distal (>10kb) Multiome | 382 | |
| chr11:67,071,470–67,071,999 | 215.2 kb | Distal (>10kb) Multiome | 302 | |
| chr11:67,117,553–67,120,314 | 262.4 kb | Distal (>10kb) Multiome | 762 |
Genomic view of the LRFN4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.