Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008]
Transcription factors with Perturb-seq knockdown data for LPCAT4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LPCAT4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LPCAT4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:34,101,337–34,102,390 | 265.2 kb | Distal (>10kb) Multiome | 810 | |
| chr15:34,209,514–34,210,513 | 157.2 kb | Distal (>10kb) Multiome | 775 | |
| chr15:34,224,706–34,225,419 | 142.2 kb | Distal (>10kb) Multiome | 856 | |
| chr15:34,337,012–34,338,557 | 29.2 kb | Distal (>10kb) Multiome | 710 | |
| chr15:34,342,481–34,343,584 | 24.0 kb | Distal (>10kb) Multiome | 845 | |
| chr15:34,366,166–34,368,049 | 820 bp | At TSS Multiome | 922 | |
| chr15:34,436,551–34,437,460 | 69.8 kb | Distal (>10kb) Multiome | 165 | |
| chr15:34,494,295–34,495,393 | 127.6 kb | Distal (>10kb) Multiome | 115 | |
| chr15:34,514,176–34,515,283 | 147.8 kb | Distal (>10kb) Multiome | 588 | |
| chr15:34,582,613–34,584,384 | 216.6 kb | Distal (>10kb) Multiome | 711 |
Genomic view of the LPCAT4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.