This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LOXL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LOXL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LOXL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:23,162,920–23,164,386 | 240.2 kb | Distal (>10kb) Multiome | 808 | |
| chr8:23,224,394–23,225,450 | 179.1 kb | Distal (>10kb) Multiome | 678 | |
| chr8:23,246,206–23,247,324 | 157.5 kb | Distal (>10kb) Multiome | 941 | |
| chr8:23,287,908–23,288,715 | 116.0 kb | Distal (>10kb) Multiome | 853 | |
| chr8:23,403,157–23,405,109 | 19 bp | At TSS Multiome | 425 | |
| chr8:23,410,448–23,410,648 | 6.3 kb | Proximal (<10kb) | 340 | |
| chr8:23,451,094–23,451,922 | 47.4 kb | Distal (>10kb) Multiome | 182 | |
| chr8:23,457,148–23,458,219 | 53.5 kb | Distal (>10kb) Multiome | 736 | |
| chr8:23,486,400–23,487,438 | 82.7 kb | Distal (>10kb) Multiome | 134 | |
| chr8:23,528,169–23,530,101 | 124.7 kb | Distal (>10kb) Multiome | 832 | |
| chr8:23,682,166–23,683,403 | 278.8 kb | Distal (>10kb) Multiome | 655 |
Genomic view of the LOXL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.