This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion. Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for LMLN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LMLN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LMLN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:197,736,285–197,737,626 | 223.2 kb | Distal (>10kb) Multiome | 760 | |
| chr3:197,749,348–197,750,809 | 210.5 kb | Distal (>10kb) Multiome | 787 | |
| chr3:197,790,656–197,791,971 | 168.9 kb | Distal (>10kb) Multiome | 906 | |
| chr3:197,949,736–197,950,528 | 10.1 kb | Distal (>10kb) Multiome | 803 | |
| chr3:197,957,094–197,957,550 | 2.7 kb | Proximal (<10kb) | 391 | |
| chr3:197,959,834–197,960,964 | 3 bp | At TSS Multiome | 773 | |
| chr3:198,080,117–198,081,882 | 120.7 kb | Distal (>10kb) Multiome | 635 |
Genomic view of the LMLN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.