This gene encodes a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. Mutations and chromosomal deletions and rearrangements in this genic region are associated with acheiropody and preaxial polydactyly, which likely result from altered sonic hedgehog expression. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LMBR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LMBR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LMBR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:155,787,041–155,788,180 | 1105.7 kb | Distal (>10kb) Multiome HiCAR | 206 | |
| chr7:155,796,797–155,797,641 | 1096.0 kb | Distal (>10kb) Multiome HiCAR | 291 | |
| chr7:155,802,850–155,806,571 | 1089.4 kb | Distal (>10kb) Multiome HiCAR | 556 | |
| chr7:156,616,217–156,617,178 | 276.5 kb | Distal (>10kb) Multiome | 381 | |
| chr7:156,639,673–156,641,488 | 252.5 kb | Distal (>10kb) Multiome | 784 | |
| chr7:156,892,088–156,893,883 | 156 bp | At TSS Multiome | 1026 | |
| chr7:156,948,934–156,950,397 | 56.5 kb | Distal (>10kb) Multiome | 895 | |
| chr7:157,003,648–157,004,372 | 110.9 kb | Distal (>10kb) Multiome | 255 | |
| chr7:157,009,113–157,012,019 | 117.6 kb | Distal (>10kb) Multiome | 793 | |
| chr7:157,013,630–157,014,425 | 120.9 kb | Distal (>10kb) Multiome | 180 | |
| chr7:157,020,746–157,021,949 | 128.1 kb | Distal (>10kb) Multiome | 146 | |
| chr7:157,138,376–157,139,695 | 245.6 kb | Distal (>10kb) Multiome | 863 |
Genomic view of the LMBR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.