The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LIPE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LIPE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LIPE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:42,132,949–42,133,545 | 289.9 kb | Distal (>10kb) Multiome | 447 | |
| chr19:42,176,787–42,177,398 | 246.1 kb | Distal (>10kb) Multiome | 381 | |
| chr19:42,216,521–42,218,719 | 205.5 kb | Distal (>10kb) Multiome | 841 | |
| chr19:42,219,693–42,220,678 | 203.0 kb | Distal (>10kb) Multiome | 735 | |
| chr19:42,241,985–42,243,820 | 180.3 kb | Distal (>10kb) Multiome | 891 | |
| chr19:42,244,086–42,245,258 | 178.4 kb | Distal (>10kb) Multiome | 768 | |
| chr19:42,253,030–42,256,178 | 169.3 kb | Distal (>10kb) Multiome | 900 | |
| chr19:42,267,812–42,269,463 | 154.3 kb | Distal (>10kb) Multiome | 887 | |
| chr19:42,279,620–42,280,909 | 143.1 kb | Distal (>10kb) Multiome | 818 | |
| chr19:42,283,173–42,285,280 | 139.2 kb | Distal (>10kb) Multiome | 739 | |
| chr19:42,301,842–42,303,114 | 120.6 kb | Distal (>10kb) Multiome | 858 | |
| chr19:42,313,206–42,313,892 | 109.7 kb | Distal (>10kb) Multiome | 515 | |
| chr19:42,323,530–42,326,402 | 97.7 kb | Distal (>10kb) Multiome | 833 | |
| chr19:42,386,878–42,387,621 | 35.9 kb | Distal (>10kb) Multiome | 602 | |
| chr19:42,396,430–42,397,663 | 26.2 kb | Distal (>10kb) Multiome | 585 | |
| chr19:42,401,221–42,402,278 | 21.4 kb | Distal (>10kb) Multiome | 475 | |
| chr19:42,422,934–42,424,367 | 534 bp | At TSS Multiome | 439 |
Genomic view of the LIPE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.