Transcription factors with Perturb-seq knockdown data for LINC02966. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02966 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02966, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:113,156,906–113,158,052 | 167.6 kb | Distal (>10kb) Multiome | 573 | |
| chr2:113,198,565–113,199,598 | 125.9 kb | Distal (>10kb) Multiome | 775 | |
| chr2:113,203,959–113,204,456 | 120.8 kb | Distal (>10kb) Multiome | 490 | |
| chr2:113,235,144–113,235,881 | 89.5 kb | Distal (>10kb) Multiome | 345 | |
| chr2:113,277,015–113,278,892 | 46.2 kb | Distal (>10kb) Multiome | 169 | |
| chr2:113,324,830–113,325,084 | at TSS | At TSS | 145 |
Genomic view of the LINC02966 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.