Transcription factors with Perturb-seq knockdown data for LINC02777. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02777 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02777, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:58,884,762–58,885,830 | at TSS | At TSS | 725 | |
| chr1:58,896,308–58,897,070 | at TSS | At TSS | 425 | |
| chr1:58,899,035–58,899,763 | 2.2 kb | Proximal (<10kb) | 629 | |
| chr1:58,903,394–58,904,485 | 6.6 kb | Proximal (<10kb) | 782 | |
| chr1:58,905,161–58,905,545 | 8.4 kb | Proximal (<10kb) | 18 |
Genomic view of the LINC02777 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.