Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LINC02754. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02754 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02754, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:67,606,302–67,607,213 | 279.6 kb | Distal (>10kb) Multiome | 781 | |
| chr11:67,619,429–67,620,391 | 266.6 kb | Distal (>10kb) Multiome | 50 | |
| chr11:67,628,876–67,631,242 | 256.1 kb | Distal (>10kb) Multiome | 1018 | |
| chr11:67,757,971–67,758,804 | 128.2 kb | Distal (>10kb) Multiome | 61 | |
| chr11:67,804,576–67,806,617 | 80.8 kb | Distal (>10kb) Multiome | 372 | |
| chr11:67,955,492–67,956,004 | 69.3 kb | Distal (>10kb) Multiome | 140 | |
| chr11:67,996,583–67,997,678 | 110.5 kb | Distal (>10kb) Multiome | 394 | |
| chr11:68,002,991–68,004,268 | 117.6 kb | Distal (>10kb) Multiome | 634 | |
| chr11:68,030,139–68,031,153 | 144.1 kb | Distal (>10kb) Multiome | 708 | |
| chr11:68,038,378–68,039,498 | 152.5 kb | Distal (>10kb) Multiome | 819 | |
| chr11:68,120,465–68,122,314 | 235.0 kb | Distal (>10kb) Multiome | 921 | |
| chr11:68,127,759–68,129,017 | 242.0 kb | Distal (>10kb) Multiome | 604 |
Genomic view of the LINC02754 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.