Transcription factors with Perturb-seq knockdown data for LINC02656. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02656 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02656, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:6,086,345–6,087,026 | 263.8 kb | Distal (>10kb) Multiome | 467 | |
| chr10:6,088,532–6,090,276 | 261.4 kb | Distal (>10kb) Multiome | 847 | |
| chr10:6,144,513–6,146,019 | 205.4 kb | Distal (>10kb) Multiome | 592 | |
| chr10:6,151,133–6,151,901 | 198.8 kb | Distal (>10kb) Multiome | 300 | |
| chr10:6,163,382–6,164,228 | 186.6 kb | Distal (>10kb) Multiome | 706 | |
| chr10:6,184,834–6,185,745 | 165.0 kb | Distal (>10kb) Multiome | 123 | |
| chr10:6,200,717–6,205,207 | 148.8 kb | Distal (>10kb) Multiome | 1010 | |
| chr10:6,579,887–6,580,963 | 230.1 kb | Distal (>10kb) Multiome | 633 |
Genomic view of the LINC02656 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.