Transcription factors with Perturb-seq knockdown data for LINC02192. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02192 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02192, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:47,873,533–47,876,243 | 12.6 kb | Distal (>10kb) Multiome | 225 | |
| chr16:47,876,915–47,877,630 | 9.5 kb | Proximal (<10kb) | 17 | |
| chr16:47,884,187–47,884,754 | 2.4 kb | Proximal (<10kb) | 44 | |
| chr16:47,886,578–47,887,983 | 206 bp | At TSS Multiome | 176 | |
| chr16:48,050,630–48,051,441 | 163.9 kb | Distal (>10kb) Multiome HiCAR | 61 | |
| chr16:48,117,171–48,117,887 | 230.5 kb | Distal (>10kb) Multiome | 334 |
Genomic view of the LINC02192 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.