Transcription factors with Perturb-seq knockdown data for LINC01950. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01950 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01950, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:106,974,406–106,974,522 | 6.3 kb | Proximal (<10kb) | 8 | |
| chr5:106,978,401–106,979,208 | 2.0 kb | Proximal (<10kb) Multiome | 146 | |
| chr5:106,979,815–106,980,414 | 454 bp | At TSS | 60 | |
| chr5:106,980,523–106,980,959 | at TSS | At TSS | 1 | |
| chr5:106,983,625–106,984,182 | 2.8 kb | Proximal (<10kb) | 59 |
Genomic view of the LINC01950 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.