Transcription factors with Perturb-seq knockdown data for LINC01814. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01814 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01814, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:8,573,534–8,573,846 | 10.0 kb | Proximal (<10kb) | 360 | |
| chr2:8,581,441–8,581,941 | 1.9 kb | Proximal (<10kb) | 155 | |
| chr2:8,582,837–8,584,915 | at TSS | At TSS | 618 | |
| chr2:8,592,607–8,593,085 | 8.8 kb | Proximal (<10kb) | 56 |
Genomic view of the LINC01814 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.