Transcription factors with Perturb-seq knockdown data for LINC01686. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01686 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01686, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:182,611,551–182,612,259 | 3.0 kb | Proximal (<10kb) | 222 | |
| chr1:182,613,228–182,613,696 | 1.6 kb | Proximal (<10kb) | 7 | |
| chr1:182,614,397–182,617,189 | at TSS | At TSS | 882 | |
| chr1:182,617,632–182,618,497 | 2.4 kb | Proximal (<10kb) | 338 |
Genomic view of the LINC01686 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.