Transcription factors with Perturb-seq knockdown data for LINC01521. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01521 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01521, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:31,080,687–31,081,783 | 265.6 kb | Distal (>10kb) Multiome | 636 | |
| chr22:31,084,596–31,085,743 | 261.7 kb | Distal (>10kb) Multiome | 448 | |
| chr22:31,098,574–31,099,237 | 247.9 kb | Distal (>10kb) Multiome | 150 | |
| chr22:31,104,824–31,105,447 | 241.7 kb | Distal (>10kb) Multiome | 187 | |
| chr22:31,107,269–31,107,915 | 239.1 kb | Distal (>10kb) Multiome | 627 | |
| chr22:31,140,179–31,140,721 | 206.3 kb | Distal (>10kb) Multiome | 244 | |
| chr22:31,160,052–31,160,698 | 186.5 kb | Distal (>10kb) Multiome | 709 | |
| chr22:31,211,835–31,212,727 | 134.6 kb | Distal (>10kb) Multiome | 769 | |
| chr22:31,290,525–31,291,372 | 56.0 kb | Distal (>10kb) Multiome | 818 | |
| chr22:31,343,299–31,343,527 | 3.2 kb | Proximal (<10kb) | 247 | |
| chr22:31,345,143–31,347,910 | 701 bp | At TSS Multiome | 954 | |
| chr22:31,362,564–31,363,231 | 16.1 kb | Distal (>10kb) Multiome | 164 | |
| chr22:31,399,166–31,400,036 | 52.7 kb | Distal (>10kb) Multiome | 913 | |
| chr22:31,489,111–31,490,354 | 143.1 kb | Distal (>10kb) Multiome | 819 | |
| chr22:31,496,060–31,496,942 | 149.7 kb | Distal (>10kb) Multiome | 769 | |
| chr22:31,630,284–31,631,283 | 284.1 kb | Distal (>10kb) Multiome | 643 |
Genomic view of the LINC01521 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.