Predicted to act upstream of or within cerebellar cortex structural organization; homeostasis of number of cells within a tissue; and regulation of gene expression. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LINC01159. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01159 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01159, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:104,861,633–104,862,667 | 4.8 kb | Proximal (<10kb) | 214 | |
| chr2:104,863,519–104,864,305 | 3.2 kb | Proximal (<10kb) | 122 | |
| chr2:104,867,042–104,868,040 | at TSS | At TSS | 123 | |
| chr2:104,872,110–104,874,183 | 4.6 kb | Proximal (<10kb) | 550 |
Genomic view of the LINC01159 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.