Transcription factors with Perturb-seq knockdown data for LINC00880. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC00880 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC00880, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:157,120,201–157,120,652 | 7.9 kb | Proximal (<10kb) | 639 | |
| chr3:157,128,378–157,128,684 | at TSS | At TSS | 345 | |
| chr3:157,129,802–157,131,179 | 1.2 kb | Proximal (<10kb) | 724 | |
| chr3:157,136,919–157,137,949 | 8.3 kb | Proximal (<10kb) | 553 |
Genomic view of the LINC00880 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.