Transcription factors with Perturb-seq knockdown data for LINC00863. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC00863 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC00863, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:87,054,811–87,055,712 | 287.7 kb | Distal (>10kb) Multiome | 179 | |
| chr10:87,093,833–87,095,937 | 247.9 kb | Distal (>10kb) Multiome | 996 | |
| chr10:87,203,498–87,204,198 | 139.2 kb | Distal (>10kb) Multiome | 295 | |
| chr10:87,342,231–87,343,299 | 346 bp | At TSS Multiome | 270 | |
| chr10:87,504,459–87,505,741 | 162.0 kb | Distal (>10kb) Multiome | 833 |
Genomic view of the LINC00863 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.