Transcription factors with Perturb-seq knockdown data for LINC00667. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC00667 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC00667, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:5,196,239–5,197,482 | 40.9 kb | Distal (>10kb) Multiome | 472 | |
| chr18:5,237,139–5,238,880 | 91 bp | At TSS Multiome | 958 | |
| chr18:5,294,279–5,297,100 | 58.2 kb | Distal (>10kb) Multiome | 946 | |
| chr18:5,456,606–5,457,058 | 218.7 kb | Distal (>10kb) Multiome | 201 |
Genomic view of the LINC00667 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.