This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. This gene is fused to a high-mobility group gene in a translocation-associated lipoma. Mutations in another LHFP-like gene result in deafness in humans and mice. Alternatively spliced transcript variants have been found; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LHFPL6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LHFPL6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LHFPL6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:39,348,142–39,348,848 | 254.6 kb | Distal (>10kb) Multiome HiCAR | 199 | |
| chr13:39,385,335–39,386,176 | 217.5 kb | Distal (>10kb) Multiome HiCAR | 268 | |
| chr13:39,600,850–39,601,008 | 2.2 kb | Proximal (<10kb) | 53 | |
| chr13:39,602,393–39,603,938 | 305 bp | At TSS Multiome | 478 | |
| chr13:39,612,147–39,612,334 | 9.0 kb | Proximal (<10kb) | 123 | |
| chr13:39,655,392–39,656,371 | 52.6 kb | Distal (>10kb) Multiome | 690 |
Genomic view of the LHFPL6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.