This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LHFPL4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LHFPL4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LHFPL4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:9,302,190–9,302,888 | 251.2 kb | Distal (>10kb) Multiome | 416 | |
| chr3:9,362,788–9,363,525 | 190.7 kb | Distal (>10kb) Multiome | 988 | |
| chr3:9,499,948–9,500,976 | 53.2 kb | Distal (>10kb) Multiome | 320 | |
| chr3:9,552,048–9,552,879 | 1.4 kb | Proximal (<10kb) Multiome | 372 | |
| chr3:9,553,391–9,554,161 | 33 bp | At TSS Multiome | 128 | |
| chr3:9,649,068–9,649,746 | 95.5 kb | Distal (>10kb) Multiome | 793 | |
| chr3:9,703,572–9,705,701 | 151.3 kb | Distal (>10kb) Multiome | 664 | |
| chr3:9,727,013–9,727,518 | 173.4 kb | Distal (>10kb) Multiome | 264 | |
| chr3:9,730,724–9,732,470 | 177.5 kb | Distal (>10kb) Multiome | 934 | |
| chr3:9,749,252–9,750,525 | 196.1 kb | Distal (>10kb) Multiome | 873 | |
| chr3:9,769,503–9,770,124 | 216.1 kb | Distal (>10kb) Multiome | 504 | |
| chr3:9,792,176–9,793,536 | 239.0 kb | Distal (>10kb) Multiome | 915 | |
| chr3:9,809,609–9,810,744 | 256.3 kb | Distal (>10kb) Multiome | 437 | |
| chr3:9,843,116–9,844,397 | 290.2 kb | Distal (>10kb) Multiome | 787 |
Genomic view of the LHFPL4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.