This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LGALS8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LGALS8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LGALS8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:236,063,919–236,065,936 | 458.8 kb | Distal (>10kb) Multiome HiCAR | 930 | |
| chr1:236,280,771–236,282,629 | 241.9 kb | Distal (>10kb) Multiome | 881 | |
| chr1:236,394,885–236,396,208 | 128.5 kb | Distal (>10kb) Multiome | 588 | |
| chr1:236,523,298–236,524,678 | at TSS | At TSS | 905 | |
| chr1:236,603,983–236,605,319 | 80.6 kb | Distal (>10kb) Multiome | 928 | |
| chr1:236,685,947–236,687,221 | 162.5 kb | Distal (>10kb) Multiome | 483 | |
| chr1:236,794,715–236,796,156 | 271.3 kb | Distal (>10kb) Multiome | 1141 |
Genomic view of the LGALS8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.