The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LGALS3BP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LGALS3BP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LGALS3BP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:78,723,107–78,723,697 | 256.5 kb | Distal (>10kb) Multiome | 236 | |
| chr17:78,781,367–78,783,044 | 197.5 kb | Distal (>10kb) Multiome | 847 | |
| chr17:78,839,825–78,841,566 | 139.0 kb | Distal (>10kb) Multiome HiCAR | 1124 | |
| chr17:78,924,768–78,925,859 | 54.5 kb | Distal (>10kb) Multiome | 498 | |
| chr17:78,971,335–78,971,892 | 8.4 kb | Proximal (<10kb) Multiome | 359 | |
| chr17:78,979,886–78,980,131 | at TSS | At TSS | 611 | |
| chr17:78,986,755–78,987,049 | 6.8 kb | Proximal (<10kb) | 302 | |
| chr17:79,009,356–79,010,250 | 29.9 kb | Distal (>10kb) Multiome | 703 | |
| chr17:79,023,888–79,024,662 | 44.4 kb | Distal (>10kb) Multiome | 348 | |
| chr17:79,074,462–79,075,529 | 94.9 kb | Distal (>10kb) Multiome | 657 | |
| chr17:79,182,908–79,183,922 | 203.6 kb | Distal (>10kb) Multiome | 257 |
Genomic view of the LGALS3BP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.