This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]
Transcription factors with Perturb-seq knockdown data for LGALS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LGALS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LGALS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:54,901,803–54,903,430 | 226.4 kb | Distal (>10kb) Multiome | 886 | |
| chr14:55,026,752–55,027,732 | 102.0 kb | Distal (>10kb) Multiome | 918 | |
| chr14:55,051,004–55,052,455 | 77.6 kb | Distal (>10kb) Multiome | 1079 | |
| chr14:55,103,022–55,103,627 | 25.9 kb | Distal (>10kb) Multiome | 700 | |
| chr14:55,128,954–55,130,369 | 89 bp | At TSS Multiome | 569 | |
| chr14:55,191,089–55,192,110 | 62.4 kb | Distal (>10kb) Multiome | 702 | |
| chr14:55,270,885–55,272,249 | 142.1 kb | Distal (>10kb) Multiome | 901 | |
| chr14:55,411,377–55,412,204 | 282.6 kb | Distal (>10kb) Multiome | 795 |
Genomic view of the LGALS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.