Transcription factors with Perturb-seq knockdown data for LEKR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LEKR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LEKR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:156,554,637–156,555,736 | 271.1 kb | Distal (>10kb) Multiome | 851 | |
| chr3:156,605,674–156,606,640 | 220.2 kb | Distal (>10kb) Multiome | 453 | |
| chr3:156,628,812–156,629,757 | 197.0 kb | Distal (>10kb) Multiome | 108 | |
| chr3:156,673,773–156,675,967 | 151.9 kb | Distal (>10kb) Multiome | 1144 | |
| chr3:156,739,496–156,740,549 | 86.2 kb | Distal (>10kb) Multiome | 99 | |
| chr3:156,815,908–156,817,589 | 9.3 kb | Proximal (<10kb) Multiome | 769 | |
| chr3:156,825,909–156,827,101 | 51 bp | At TSS Multiome | 901 | |
| chr3:156,897,559–156,898,592 | 71.7 kb | Distal (>10kb) Multiome | 147 | |
| chr3:157,108,708–157,110,262 | 283.3 kb | Distal (>10kb) Multiome HiCAR | 379 | |
| chr3:157,129,802–157,131,179 | 304.3 kb | Distal (>10kb) Multiome HiCAR | 724 |
Genomic view of the LEKR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.