Predicted to be involved in intraciliary transport. Predicted to be active in axoneme. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LCA5L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LCA5L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LCA5L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:39,182,840–39,184,214 | 262.1 kb | Distal (>10kb) Multiome | 1028 | |
| chr21:39,312,364–39,314,680 | 131.9 kb | Distal (>10kb) Multiome | 1121 | |
| chr21:39,332,179–39,332,739 | 113.4 kb | Distal (>10kb) Multiome | 188 | |
| chr21:39,348,209–39,350,114 | 96.5 kb | Distal (>10kb) Multiome | 923 | |
| chr21:39,380,111–39,380,888 | 65.4 kb | Distal (>10kb) Multiome | 663 | |
| chr21:39,387,404–39,389,039 | 57.0 kb | Distal (>10kb) Multiome | 713 | |
| chr21:39,429,900–39,431,278 | 15.1 kb | Distal (>10kb) Multiome | 277 | |
| chr21:39,438,995–39,439,191 | 6.6 kb | Proximal (<10kb) | 20 | |
| chr21:39,441,607–39,441,781 | 4.0 kb | Proximal (<10kb) | 103 | |
| chr21:39,445,343–39,446,179 | 32 bp | At TSS Multiome | 837 | |
| chr21:39,450,801–39,451,150 | 5.0 kb | Proximal (<10kb) | 29 | |
| chr21:39,451,559–39,452,036 | 6.0 kb | Proximal (<10kb) Multiome | 267 | |
| chr21:39,612,590–39,613,211 | 167.1 kb | Distal (>10kb) Multiome | 208 |
Genomic view of the LCA5L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.