Enables RNA binding activity and myosin binding activity. Involved in positive regulation of collagen biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LARP6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LARP6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LARP6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:70,584,932–70,585,627 | 268.8 kb | Distal (>10kb) Multiome | 463 | |
| chr15:70,762,521–70,764,044 | 90.5 kb | Distal (>10kb) Multiome | 805 | |
| chr15:70,853,264–70,854,729 | 4 bp | At TSS Multiome | 472 | |
| chr15:70,891,888–70,893,094 | 38.4 kb | Distal (>10kb) Multiome | 794 | |
| chr15:71,085,589–71,086,284 | 231.8 kb | Distal (>10kb) Multiome | 153 | |
| chr15:71,114,765–71,116,364 | 261.3 kb | Distal (>10kb) Multiome | 625 |
Genomic view of the LARP6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.