The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LAMP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LAMP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LAMP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:120,250,502–120,251,241 | 218.5 kb | Distal (>10kb) Multiome | 662 | |
| chrX:120,309,330–120,309,857 | 159.6 kb | Distal (>10kb) Multiome HiCAR | 479 | |
| chrX:120,468,789–120,469,502 | 45 bp | At TSS Multiome | 589 | |
| chrX:120,485,807–120,486,482 | 16.8 kb | Distal (>10kb) Multiome | 698 | |
| chrX:120,560,301–120,561,794 | 91.9 kb | Distal (>10kb) Multiome | 727 | |
| chrX:120,603,687–120,604,407 | 134.7 kb | Distal (>10kb) Multiome | 581 | |
| chrX:120,629,690–120,630,593 | 160.8 kb | Distal (>10kb) Multiome | 673 |
Genomic view of the LAMP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.