This gene belongs to the ESO/LAGE gene family, members of which are clustered together on chromosome Xq28, and have similar exon-intron structures. Unlike the other family members which are normally expressed only in testis and activated in a wide range of human tumors, this gene is ubiquitously expressed in somatic tissues. The latter, combined with the finding that it is highly conserved in mouse and rat, suggests that the encoded protein is functionally important. An intronless pseudogene with high sequence similarity to this gene is located on chromosome 9. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LAGE3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LAGE3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LAGE3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:154,368,993–154,370,053 | 109.7 kb | Distal (>10kb) Multiome | 546 | |
| chrX:154,370,757–154,372,188 | 107.9 kb | Distal (>10kb) Multiome | 764 | |
| chrX:154,378,063–154,379,701 | 100.3 kb | Distal (>10kb) Multiome | 687 | |
| chrX:154,397,430–154,398,941 | 81.1 kb | Distal (>10kb) Multiome | 871 | |
| chrX:154,409,052–154,409,671 | 69.9 kb | Distal (>10kb) Multiome | 396 | |
| chrX:154,428,419–154,428,969 | 50.7 kb | Distal (>10kb) Multiome | 601 | |
| chrX:154,436,501–154,437,435 | 42.4 kb | Distal (>10kb) Multiome | 448 | |
| chrX:154,443,986–154,444,454 | 35.1 kb | Distal (>10kb) Multiome | 329 | |
| chrX:154,457,605–154,458,763 | 21.2 kb | Distal (>10kb) Multiome | 467 | |
| chrX:154,478,385–154,479,590 | 207 bp | At TSS Multiome | 707 | |
| chrX:154,486,385–154,487,035 | 7.5 kb | Proximal (<10kb) Multiome | 437 | |
| chrX:154,490,259–154,491,245 | 11.5 kb | Distal (>10kb) Multiome | 567 | |
| chrX:154,515,811–154,517,059 | 37.1 kb | Distal (>10kb) Multiome | 590 | |
| chrX:154,546,514–154,547,906 | 67.9 kb | Distal (>10kb) Multiome | 691 | |
| chrX:154,762,385–154,763,339 | 283.5 kb | Distal (>10kb) Multiome | 675 |
Genomic view of the LAGE3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.