Predicted to enable ATP binding activity. Predicted to be involved in tRNA wobble uridine modification. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KTI12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KTI12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KTI12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:51,877,934–51,879,493 | 154.9 kb | Distal (>10kb) Multiome | 1012 | |
| chr1:51,989,938–51,991,038 | 43.2 kb | Distal (>10kb) Multiome | 410 | |
| chr1:52,032,841–52,033,969 | 121 bp | At TSS Multiome | 829 | |
| chr1:52,054,893–52,057,012 | 21.3 kb | Distal (>10kb) Multiome | 1080 | |
| chr1:52,141,669–52,142,926 | 108.3 kb | Distal (>10kb) Multiome | 839 |
Genomic view of the KTI12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.