Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KLHL11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLHL11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLHL11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:41,579,549–41,580,064 | 285.7 kb | Distal (>10kb) Multiome | 335 | |
| chr17:41,647,765–41,648,495 | 217.3 kb | Distal (>10kb) Multiome | 519 | |
| chr17:41,665,564–41,667,291 | 199.4 kb | Distal (>10kb) Multiome | 883 | |
| chr17:41,688,103–41,690,064 | 176.1 kb | Distal (>10kb) Multiome | 1236 | |
| chr17:41,733,761–41,735,187 | 130.7 kb | Distal (>10kb) Multiome | 577 | |
| chr17:41,738,054–41,738,690 | 127.1 kb | Distal (>10kb) Multiome | 596 | |
| chr17:41,784,980–41,787,229 | 78.6 kb | Distal (>10kb) Multiome | 958 | |
| chr17:41,793,527–41,794,326 | 71.5 kb | Distal (>10kb) Multiome | 597 | |
| chr17:41,800,647–41,802,040 | 64.5 kb | Distal (>10kb) Multiome | 766 | |
| chr17:41,811,252–41,813,275 | 52.6 kb | Distal (>10kb) Multiome | 997 | |
| chr17:41,835,756–41,836,400 | 29.2 kb | Distal (>10kb) Multiome | 568 | |
| chr17:41,864,608–41,865,695 | 25 bp | At TSS Multiome | 913 | |
| chr17:41,918,026–41,919,794 | 53.8 kb | Distal (>10kb) Multiome | 956 | |
| chr17:41,930,220–41,930,908 | 65.1 kb | Distal (>10kb) Multiome | 915 | |
| chr17:41,965,771–41,967,327 | 100.6 kb | Distal (>10kb) Multiome | 920 | |
| chr17:42,016,953–42,018,102 | 152.0 kb | Distal (>10kb) Multiome | 991 | |
| chr17:42,019,726–42,020,334 | 154.6 kb | Distal (>10kb) Multiome | 791 | |
| chr17:42,050,326–42,051,046 | 185.2 kb | Distal (>10kb) Multiome | 514 | |
| chr17:42,107,497–42,108,335 | 242.4 kb | Distal (>10kb) Multiome | 357 | |
| chr17:42,120,858–42,121,715 | 255.8 kb | Distal (>10kb) Multiome | 559 | |
| chr17:42,122,176–42,123,003 | 257.3 kb | Distal (>10kb) Multiome | 169 | |
| chr17:42,154,717–42,156,309 | 289.7 kb | Distal (>10kb) Multiome | 770 |
Genomic view of the KLHL11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.