The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for KIN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:7,513,605–7,514,402 | 273.9 kb | Distal (>10kb) Multiome | 112 | |
| chr10:7,540,399–7,542,174 | 247.1 kb | Distal (>10kb) Multiome | 420 | |
| chr10:7,551,477–7,552,685 | 235.9 kb | Distal (>10kb) Multiome | 160 | |
| chr10:7,605,258–7,606,229 | 182.2 kb | Distal (>10kb) Multiome | 80 | |
| chr10:7,618,865–7,620,103 | 168.4 kb | Distal (>10kb) Multiome | 246 | |
| chr10:7,667,487–7,668,354 | 120.3 kb | Distal (>10kb) Multiome | 159 | |
| chr10:7,787,377–7,789,109 | 97 bp | At TSS Multiome | 843 | |
| chr10:7,795,727–7,795,951 | 7.7 kb | Proximal (<10kb) | 151 | |
| chr10:7,818,056–7,819,396 | 30.5 kb | Distal (>10kb) Multiome | 897 | |
| chr10:8,044,436–8,045,614 | 257.3 kb | Distal (>10kb) Multiome | 246 | |
| chr10:8,047,568–8,048,598 | 260.1 kb | Distal (>10kb) Multiome | 190 | |
| chr10:8,049,343–8,052,545 | 261.8 kb | Distal (>10kb) Multiome | 796 | |
| chr10:8,053,150–8,055,390 | 265.5 kb | Distal (>10kb) Multiome | 590 | |
| chr10:8,071,272–8,072,513 | 283.9 kb | Distal (>10kb) Multiome | 160 |
Genomic view of the KIN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.