KIF3A

kinesin family member 3A | FLA10, KLP-20

Enables protein phosphatase binding activity; small GTPase binding activity; and spectrin binding activity. Involved in protein localization to cell junction and protein transport. Located in centriole; centrosome; and spindle microtubule. Part of kinesin II complex. Biomarker of silicosis. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 47 terms

ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)anterograde axonal transport (GO:0008089)axon cytoplasm (GO:1904115)centriole (GO:0005814)centriole (GO:0005814)centriole-centriole cohesion (GO:0010457)centrosome (GO:0005813)ciliary tip (GO:0097542)cilium (GO:0005929)cilium (GO:0005929)cilium (GO:0005929)cilium assembly (GO:0060271)cilium assembly (GO:0060271)cytoplasm (GO:0005737)cytoskeletal protein binding (GO:0008092)cytoskeleton (GO:0005856)cytosol (GO:0005829)cytosol (GO:0005829)extracellular exosome (GO:0070062)kinesin II complex (GO:0016939)kinesin II complex (GO:0016939)kinesin complex (GO:0005871)microtubule (GO:0005874)microtubule anchoring at centrosome (GO:0034454)microtubule binding (GO:0008017)microtubule binding (GO:0008017)microtubule cytoskeleton (GO:0015630)microtubule motor activity (GO:0003777)microtubule motor activity (GO:0003777)microtubule motor activity (GO:0003777)microtubule-based movement (GO:0007018)non-motile cilium (GO:0097730)organelle organization (GO:0006996)plus-end-directed microtubule motor activity (GO:0008574)plus-end-directed vesicle transport along microtubule (GO:0072383)positive regulation of smoothened signaling pathway (GO:0045880)protein binding (GO:0005515)protein localization to cell junction (GO:1902414)protein localization to non-motile cilium (GO:0097499)protein phosphatase binding (GO:0019903)protein transport (GO:0015031)protein-containing complex binding (GO:0044877)small GTPase binding (GO:0031267)spectrin binding (GO:0030507)spindle microtubule (GO:0005876)transport along microtubule (GO:0010970)

Expression (TPM)

TFs regulating KIF3A 0 TFs

Transcription factors with Perturb-seq knockdown data for KIF3A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF3A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to KIF3A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF3A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr5:132,489,909–132,492,004	246.7 kb	Distal (>10kb) Multiome	899
chr5:132,495,550–132,497,614	241.1 kb	Distal (>10kb) Multiome	946
chr5:132,526,534–132,527,026	210.7 kb	Distal (>10kb) Multiome	329
chr5:132,556,575–132,557,723	180.6 kb	Distal (>10kb) Multiome	1071
chr5:132,655,819–132,656,736	81.3 kb	Distal (>10kb) Multiome	235
chr5:132,736,904–132,738,172	5 bp	At TSS Multiome	706
chr5:132,746,941–132,748,230	10.2 kb	Distal (>10kb) Multiome	369
chr5:132,776,389–132,777,915	39.8 kb	Distal (>10kb) Multiome	587
chr5:132,813,194–132,815,033	77.0 kb	Distal (>10kb) Multiome	418
chr5:132,822,729–132,823,756	85.7 kb	Distal (>10kb) Multiome	258
chr5:132,825,176–132,826,484	88.2 kb	Distal (>10kb) Multiome	208
chr5:132,829,647–132,831,156	92.8 kb	Distal (>10kb) Multiome	877
chr5:132,866,046–132,867,186	129.0 kb	Distal (>10kb) Multiome	955
chr5:132,963,042–132,964,332	226.2 kb	Distal (>10kb) Multiome	1068
chr5:133,026,009–133,027,021	289.0 kb	Distal (>10kb) Multiome	754

Genome Browser

Genomic view of the KIF3A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.