Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in anterograde dendritic transport of neurotransmitter receptor complex and cell projection organization. Predicted to act upstream of or within microtubule-based process; protein-containing complex localization; and vesicle-mediated transport. Predicted to be located in cytosol. Predicted to be part of kinesin complex. Predicted to be active in several cellular components, including cilium; microtubule cytoskeleton; and postsynapse. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for KIF17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:20,485,233–20,485,959 | 232.2 kb | Distal (>10kb) Multiome | 348 | |
| chr1:20,486,131–20,487,438 | 231.0 kb | Distal (>10kb) Multiome | 760 | |
| chr1:20,493,822–20,494,241 | 223.9 kb | Distal (>10kb) Multiome | 430 | |
| chr1:20,507,717–20,508,432 | 209.9 kb | Distal (>10kb) Multiome | 811 | |
| chr1:20,552,019–20,553,890 | 164.4 kb | Distal (>10kb) Multiome | 518 | |
| chr1:20,625,186–20,625,881 | 92.5 kb | Distal (>10kb) Multiome | 123 | |
| chr1:20,633,024–20,634,989 | 84.2 kb | Distal (>10kb) Multiome | 759 | |
| chr1:20,661,099–20,662,130 | 56.5 kb | Distal (>10kb) Multiome | 784 | |
| chr1:20,696,319–20,697,384 | 21.1 kb | Distal (>10kb) Multiome | 727 | |
| chr1:20,717,384–20,718,370 | 146 bp | At TSS Multiome | 440 | |
| chr1:20,731,726–20,733,330 | 14.3 kb | Distal (>10kb) Multiome | 718 | |
| chr1:20,786,021–20,787,857 | 68.9 kb | Distal (>10kb) Multiome | 963 |
Genomic view of the KIF17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.