Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KIAA1549L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIAA1549L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIAA1549L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:33,160,986–33,162,028 | 214.6 kb | Distal (>10kb) Multiome | 908 | |
| chr11:33,256,736–33,259,047 | 117.6 kb | Distal (>10kb) Multiome | 993 | |
| chr11:33,375,703–33,377,039 | 259 bp | At TSS Multiome | 329 | |
| chr11:33,699,853–33,701,513 | 324.8 kb | Distal (>10kb) Multiome HiCAR | 711 |
Genomic view of the KIAA1549L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.