This gene encodes a conserved centrosomal protein that functions in ciliogenesis and responds to hedgehog signaling. Mutations in this gene causes Joubert syndrome 23. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Aug 2016]
Transcription factors with Perturb-seq knockdown data for KIAA0586. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIAA0586 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIAA0586, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:58,151,365–58,152,866 | 275.5 kb | Distal (>10kb) Multiome | 506 | |
| chr14:58,199,683–58,200,642 | 227.7 kb | Distal (>10kb) Multiome | 673 | |
| chr14:58,244,179–58,245,432 | 182.9 kb | Distal (>10kb) Multiome | 789 | |
| chr14:58,297,373–58,299,879 | 129.5 kb | Distal (>10kb) Multiome | 1029 | |
| chr14:58,395,454–58,396,694 | 31.7 kb | Distal (>10kb) Multiome | 791 | |
| chr14:58,426,724–58,428,061 | 65 bp | At TSS Multiome | 996 | |
| chr14:58,625,028–58,626,860 | 197.9 kb | Distal (>10kb) Multiome | 240 | |
| chr14:58,637,252–58,639,111 | 210.2 kb | Distal (>10kb) Multiome | 493 |
Genomic view of the KIAA0586 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.