KHNYN

KH and NYN domain containing | KIAA0323

The protein encoded by this gene contains a ribonuclease NYN domain and belongs to the N4BP1 family. The protein is a cofactor for the zinc finger antiviral protein (ZAP protein) which targets viral RNA for degradation and restricts SARS-CoV-2 infection. [provided by RefSeq, Sep 2021]

Biological processes 10 terms

3'-UTR-mediated mRNA destabilization (GO:0061158)RNA binding (GO:0003723)RNA endonuclease activity (GO:0004521)biological_process (GO:0008150)cellular_component (GO:0005575)cytoplasmic ribonucleoprotein granule (GO:0036464)mRNA binding (GO:0003729)molecular_function (GO:0003674)nucleus (GO:0005634)protein binding (GO:0005515)

Expression (TPM)

TFs regulating KHNYN 0 TFs

Transcription factors with Perturb-seq knockdown data for KHNYN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KHNYN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to KHNYN

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KHNYN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:24,135,549–24,136,884	293.9 kb	Distal (>10kb) Multiome	778
chr14:24,140,526–24,142,331	288.3 kb	Distal (>10kb) Multiome	1034
chr14:24,146,204–24,148,108	283.1 kb	Distal (>10kb) Multiome	918
chr14:24,160,877–24,161,762	268.7 kb	Distal (>10kb) Multiome	970
chr14:24,171,489–24,172,698	258.1 kb	Distal (>10kb) Multiome	365
chr14:24,188,229–24,189,111	241.1 kb	Distal (>10kb) Multiome	1074
chr14:24,195,072–24,196,365	234.4 kb	Distal (>10kb) Multiome	1059
chr14:24,212,871–24,213,884	216.5 kb	Distal (>10kb) Multiome	1036
chr14:24,215,523–24,216,241	213.9 kb	Distal (>10kb) Multiome	955
chr14:24,231,706–24,233,147	197.4 kb	Distal (>10kb) Multiome	1027
chr14:24,241,845–24,243,572	187.4 kb	Distal (>10kb) Multiome	1077
chr14:24,270,770–24,271,924	158.5 kb	Distal (>10kb) Multiome	1089
chr14:24,299,120–24,300,273	130.2 kb	Distal (>10kb) Multiome	892
chr14:24,332,251–24,333,127	97.4 kb	Distal (>10kb) Multiome HiCAR	740
chr14:24,365,652–24,366,243	64.2 kb	Distal (>10kb) Multiome HiCAR	668
chr14:24,366,594–24,369,358	62.7 kb	Distal (>10kb) Multiome HiCAR	921
chr14:24,388,547–24,389,510	41.0 kb	Distal (>10kb) Multiome	161
chr14:24,398,424–24,399,423	31.0 kb	Distal (>10kb) Multiome	354
chr14:24,427,322–24,427,501	2.5 kb	Proximal (<10kb)	208
chr14:24,429,597–24,431,070	131 bp	At TSS Multiome	903
chr14:24,431,554–24,432,205	2.0 kb	Proximal (<10kb) Multiome	604
chr14:24,436,789–24,436,996	6.8 kb	Proximal (<10kb)	265
chr14:24,441,935–24,443,373	12.7 kb	Distal (>10kb) Multiome	1072
chr14:24,481,599–24,482,121	51.9 kb	Distal (>10kb) Multiome	593

Genome Browser

Genomic view of the KHNYN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.