Transcription factors with Perturb-seq knockdown data for KHDC1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KHDC1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KHDC1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:73,262,731–73,263,555 | 20 bp | At TSS Multiome | 460 | |
| chr6:73,314,466–73,315,532 | 51.8 kb | Distal (>10kb) Multiome | 137 | |
| chr6:73,348,234–73,349,695 | 86.2 kb | Distal (>10kb) Multiome | 281 | |
| chr6:73,388,539–73,389,752 | 125.8 kb | Distal (>10kb) Multiome | 579 | |
| chr6:73,450,878–73,452,652 | 188.8 kb | Distal (>10kb) Multiome | 510 | |
| chr6:73,461,207–73,462,355 | 198.5 kb | Distal (>10kb) Multiome | 806 | |
| chr6:73,511,142–73,516,574 | 251.1 kb | Distal (>10kb) Multiome | 913 | |
| chr6:73,520,105–73,522,117 | 258.0 kb | Distal (>10kb) Multiome | 1220 |
Genomic view of the KHDC1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.