This gene encodes a cytoplasmic regulatory protein that plays a role in the cellular response to oxidative and electrophilic stress. The encoded protein regulates NRF2, a transcription factor that controls the expression of antioxidant and cytoprotective genes. Under non-stress conditions, KEAP1 binds NRF2 and promotes its ubiquitination and proteasomal degradation, thereby maintaining low NRF2 levels. During oxidative or electrophilic stress, conformational changes in KEAP1 impair its ability to promote NRF2 degradation, allowing NRF2 to activate genes that protect cells from oxidative damage and toxic insults. [provided by RefSeq, Mar 2026]
Transcription factors with Perturb-seq knockdown data for KEAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KEAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KEAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:10,230,671–10,231,665 | 271.3 kb | Distal (>10kb) Multiome | 595 | |
| chr19:10,251,723–10,252,663 | 250.7 kb | Distal (>10kb) Multiome | 969 | |
| chr19:10,269,513–10,270,051 | 233.0 kb | Distal (>10kb) Multiome | 523 | |
| chr19:10,270,913–10,271,370 | 231.5 kb | Distal (>10kb) Multiome | 753 | |
| chr19:10,286,849–10,287,511 | 215.6 kb | Distal (>10kb) Multiome | 621 | |
| chr19:10,288,709–10,290,833 | 213.8 kb | Distal (>10kb) Multiome | 688 | |
| chr19:10,292,085–10,293,198 | 210.2 kb | Distal (>10kb) Multiome | 441 | |
| chr19:10,315,359–10,316,478 | 186.7 kb | Distal (>10kb) Multiome | 830 | |
| chr19:10,332,816–10,334,107 | 169.2 kb | Distal (>10kb) Multiome | 882 | |
| chr19:10,334,573–10,335,642 | 167.7 kb | Distal (>10kb) Multiome | 584 | |
| chr19:10,352,359–10,354,435 | 150.0 kb | Distal (>10kb) Multiome | 447 | |
| chr19:10,380,209–10,381,218 | 122.0 kb | Distal (>10kb) Multiome | 874 | |
| chr19:10,403,282–10,404,914 | 99.0 kb | Distal (>10kb) Multiome | 794 | |
| chr19:10,416,245–10,417,312 | 86.0 kb | Distal (>10kb) Multiome | 988 | |
| chr19:10,417,499–10,421,409 | 82.4 kb | Distal (>10kb) Multiome | 801 | |
| chr19:10,424,198–10,424,839 | 78.2 kb | Distal (>10kb) Multiome | 563 | |
| chr19:10,431,990–10,432,435 | 70.5 kb | Distal (>10kb) Multiome | 301 | |
| chr19:10,460,915–10,461,960 | 41.3 kb | Distal (>10kb) Multiome | 340 | |
| chr19:10,502,251–10,503,615 | 125 bp | At TSS Multiome | 1013 | |
| chr19:10,505,683–10,505,866 | 3.0 kb | Proximal (<10kb) | 252 | |
| chr19:10,514,009–10,514,960 | 11.7 kb | Distal (>10kb) Multiome | 172 | |
| chr19:10,517,347–10,518,104 | 15.1 kb | Distal (>10kb) Multiome | 338 | |
| chr19:10,543,499–10,544,302 | 41.1 kb | Distal (>10kb) Multiome | 617 | |
| chr19:10,565,054–10,566,439 | 63.3 kb | Distal (>10kb) Multiome | 923 | |
| chr19:10,568,225–10,569,839 | 66.3 kb | Distal (>10kb) Multiome | 871 | |
| chr19:10,602,117–10,602,945 | 99.8 kb | Distal (>10kb) Multiome | 518 | |
| chr19:10,625,339–10,625,984 | 122.9 kb | Distal (>10kb) Multiome | 451 | |
| chr19:10,653,364–10,655,129 | 151.4 kb | Distal (>10kb) Multiome | 1086 | |
| chr19:10,695,264–10,696,403 | 193.2 kb | Distal (>10kb) Multiome HiCAR | 831 | |
| chr19:10,701,273–10,702,291 | 198.8 kb | Distal (>10kb) Multiome HiCAR | 889 | |
| chr19:10,717,121–10,718,717 | 215.1 kb | Distal (>10kb) Multiome | 849 |
Genomic view of the KEAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.