This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for KDM8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KDM8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KDM8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:27,109,686–27,110,564 | 93.5 kb | Distal (>10kb) Multiome | 416 | |
| chr16:27,203,194–27,204,605 | 260 bp | At TSS Multiome | 957 | |
| chr16:27,313,498–27,314,279 | 110.4 kb | Distal (>10kb) Multiome | 709 | |
| chr16:27,326,759–27,327,565 | 123.7 kb | Distal (>10kb) Multiome | 524 |
Genomic view of the KDM8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.