KDM4E

lysine demethylase 4E | JMJD2E, KDM5E, KDM4DL

The protein encoded by this intronless gene is a member of a large family of histone lysine demethylases, which use oxygen and 2-oxoglutarate to demethylate di- and trimethylated lys9 of histone H3. Derepression of genes by demethylases is sometimes involved in viral infection or carcinogenesis, so inhibitors of these enzymes are desired. [provided by RefSeq, Dec 2016]

Biological processes 11 terms

chromatin (GO:0000785)chromatin remodeling (GO:0006338)histone H3K56me2/H3K56me3 demethylase activity (GO:0140760)histone H3K9 demethylase activity (GO:0032454)histone H3K9me2/H3K9me3 demethylase activity (GO:0140684)histone H3K9me2/H3K9me3 demethylase activity (GO:0140684)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)regulation of gene expression (GO:0010468)

Expression (TPM)