Enables histone H3K9me2/H3K9me3 demethylase activity. Involved in inflammatory response. Acts upstream of or within several processes, including cellular response to ionizing radiation; double-strand break repair via homologous recombination; and positive regulation of double-strand break repair via nonhomologous end joining. Located in site of double-strand break. Biomarker of nephroblastoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KDM4D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KDM4D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KDM4D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:94,734,354–94,735,444 | 239.0 kb | Distal (>10kb) Multiome | 313 | |
| chr11:94,740,333–94,741,667 | 233.0 kb | Distal (>10kb) Multiome | 433 | |
| chr11:94,766,900–94,769,104 | 206.6 kb | Distal (>10kb) Multiome | 701 | |
| chr11:94,866,030–94,867,452 | 107.0 kb | Distal (>10kb) Multiome | 112 | |
| chr11:94,973,096–94,974,006 | 96 bp | At TSS Multiome | 740 | |
| chr11:95,066,821–95,068,191 | 93.7 kb | Distal (>10kb) Multiome | 721 | |
| chr11:95,089,389–95,090,696 | 116.1 kb | Distal (>10kb) Multiome | 660 | |
| chr11:95,107,207–95,108,126 | 134.0 kb | Distal (>10kb) Multiome | 232 | |
| chr11:95,144,387–95,145,222 | 171.2 kb | Distal (>10kb) Multiome | 127 | |
| chr11:95,149,652–95,152,295 | 176.2 kb | Distal (>10kb) Multiome | 685 | |
| chr11:95,229,933–95,232,611 | 257.6 kb | Distal (>10kb) Multiome | 696 |
Genomic view of the KDM4D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.