Predicted to enable identical protein binding activity. Predicted to be involved in monoatomic ion transmembrane transport and protein homooligomerization. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KCTD18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCTD18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCTD18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:199,955,094–199,956,570 | 554.5 kb | Distal (>10kb) Multiome HiCAR | 1078 | |
| chr2:200,305,837–200,307,750 | 203.2 kb | Distal (>10kb) Multiome | 864 | |
| chr2:200,481,420–200,481,868 | 28.5 kb | Distal (>10kb) Multiome | 350 | |
| chr2:200,509,374–200,510,438 | 2 bp | At TSS Multiome | 876 | |
| chr2:200,525,770–200,526,701 | 16.1 kb | Distal (>10kb) Multiome | 869 | |
| chr2:200,585,716–200,586,842 | 76.0 kb | Distal (>10kb) Multiome | 627 | |
| chr2:200,648,397–200,649,297 | 138.7 kb | Distal (>10kb) Multiome | 229 | |
| chr2:200,713,048–200,713,472 | 203.2 kb | Distal (>10kb) Multiome | 763 | |
| chr2:200,736,302–200,737,549 | 226.9 kb | Distal (>10kb) Multiome | 210 |
Genomic view of the KCTD18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.