Transcription factors with Perturb-seq knockdown data for KCNK15-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCNK15-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCNK15-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:44,733,470–44,733,650 | 5.2 kb | Proximal (<10kb) | 224 | |
| chr20:44,736,241–44,736,565 | 2.3 kb | Proximal (<10kb) | 362 | |
| chr20:44,738,890–44,739,128 | at TSS | At TSS | 217 | |
| chr20:44,745,652–44,746,316 | 6.8 kb | Proximal (<10kb) | 321 | |
| chr20:44,747,580–44,747,787 | 8.7 kb | Proximal (<10kb) | 288 |
Genomic view of the KCNK15-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.