KCNJ14
potassium inwardly rectifying channel subfamily J member 14 | IRK4, Kir2.4

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013]

Biological processes 9 terms
Expression (TPM)
KCNJ14 — as a Regulated Gene

TFs regulating KCNJ14 0 TFs

Transcription factors with Perturb-seq knockdown data for KCNJ14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCNJ14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to KCNJ14

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCNJ14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:48,169,480–48,171,282 285.1 kb Distal (>10kb) Multiome 950
chr19:48,203,709–48,204,551 251.5 kb Distal (>10kb) Multiome 741
chr19:48,271,198–48,272,050 184.0 kb Distal (>10kb) Multiome 562
chr19:48,290,181–48,291,716 165.0 kb Distal (>10kb) Multiome 666
chr19:48,320,062–48,322,328 134.0 kb Distal (>10kb) Multiome 826
chr19:48,330,094–48,330,787 125.3 kb Distal (>10kb) Multiome 460
chr19:48,332,701–48,333,506 122.6 kb Distal (>10kb) Multiome 615
chr19:48,333,584–48,334,372 121.4 kb Distal (>10kb) Multiome 554
chr19:48,363,062–48,364,710 91.3 kb Distal (>10kb) Multiome 940
chr19:48,390,663–48,391,935 64.0 kb Distal (>10kb) Multiome 816
chr19:48,397,916–48,399,301 56.7 kb Distal (>10kb) Multiome 619
chr19:48,399,411–48,400,900 55.1 kb Distal (>10kb) Multiome 548
chr19:48,414,121–48,416,085 40.0 kb Distal (>10kb) Multiome 298
chr19:48,445,379–48,446,456 9.7 kb Proximal (<10kb) Multiome 845
chr19:48,462,365–48,462,576 6.8 kb Proximal (<10kb) 207
chr19:48,468,758–48,470,027 13.6 kb Distal (>10kb) Multiome 860
chr19:48,490,661–48,494,449 37.7 kb Distal (>10kb) Multiome 633
chr19:48,500,898–48,503,050 46.5 kb Distal (>10kb) Multiome 656
chr19:48,510,624–48,511,212 55.2 kb Distal (>10kb) Multiome 268
chr19:48,513,480–48,514,294 58.3 kb Distal (>10kb) Multiome 585
chr19:48,614,318–48,615,255 159.3 kb Distal (>10kb) Multiome 524
chr19:48,618,726–48,619,869 163.8 kb Distal (>10kb) Multiome 1012
chr19:48,623,839–48,624,688 168.7 kb Distal (>10kb) Multiome 529
chr19:48,629,369–48,631,306 174.4 kb Distal (>10kb) Multiome 402
chr19:48,634,242–48,636,244 179.0 kb Distal (>10kb) Multiome 868
chr19:48,636,802–48,639,603 182.1 kb Distal (>10kb) Multiome 956
chr19:48,645,454–48,647,163 191.0 kb Distal (>10kb) Multiome 750
chr19:48,675,421–48,675,873 220.0 kb Distal (>10kb) Multiome 415
chr19:48,695,830–48,697,033 240.5 kb Distal (>10kb) Multiome 253
chr19:48,713,646–48,714,846 258.7 kb Distal (>10kb) Multiome 719
chr19:48,716,551–48,717,038 261.3 kb Distal (>10kb) Multiome 241
chr19:48,720,420–48,721,301 265.3 kb Distal (>10kb) Multiome 689
chr19:48,735,001–48,735,602 279.7 kb Distal (>10kb) Multiome 161
chr19:48,738,441–48,739,812 283.3 kb Distal (>10kb) Multiome 743
chr19:48,741,194–48,741,939 286.1 kb Distal (>10kb) Multiome 350
chr19:48,746,830–48,747,395 291.5 kb Distal (>10kb) Multiome 402
chr19:48,752,314–48,753,547 297.4 kb Distal (>10kb) Multiome 545

Genome Browser

Genomic view of the KCNJ14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:48,159,480 – 48,763,547
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq