Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013]
Transcription factors with Perturb-seq knockdown data for KCNJ14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCNJ14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCNJ14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:48,169,480–48,171,282 | 285.1 kb | Distal (>10kb) Multiome | 950 | |
| chr19:48,203,709–48,204,551 | 251.5 kb | Distal (>10kb) Multiome | 741 | |
| chr19:48,271,198–48,272,050 | 184.0 kb | Distal (>10kb) Multiome | 562 | |
| chr19:48,290,181–48,291,716 | 165.0 kb | Distal (>10kb) Multiome | 666 | |
| chr19:48,320,062–48,322,328 | 134.0 kb | Distal (>10kb) Multiome | 826 | |
| chr19:48,330,094–48,330,787 | 125.3 kb | Distal (>10kb) Multiome | 460 | |
| chr19:48,332,701–48,333,506 | 122.6 kb | Distal (>10kb) Multiome | 615 | |
| chr19:48,333,584–48,334,372 | 121.4 kb | Distal (>10kb) Multiome | 554 | |
| chr19:48,363,062–48,364,710 | 91.3 kb | Distal (>10kb) Multiome | 940 | |
| chr19:48,390,663–48,391,935 | 64.0 kb | Distal (>10kb) Multiome | 816 | |
| chr19:48,397,916–48,399,301 | 56.7 kb | Distal (>10kb) Multiome | 619 | |
| chr19:48,399,411–48,400,900 | 55.1 kb | Distal (>10kb) Multiome | 548 | |
| chr19:48,414,121–48,416,085 | 40.0 kb | Distal (>10kb) Multiome | 298 | |
| chr19:48,445,379–48,446,456 | 9.7 kb | Proximal (<10kb) Multiome | 845 | |
| chr19:48,462,365–48,462,576 | 6.8 kb | Proximal (<10kb) | 207 | |
| chr19:48,468,758–48,470,027 | 13.6 kb | Distal (>10kb) Multiome | 860 | |
| chr19:48,490,661–48,494,449 | 37.7 kb | Distal (>10kb) Multiome | 633 | |
| chr19:48,500,898–48,503,050 | 46.5 kb | Distal (>10kb) Multiome | 656 | |
| chr19:48,510,624–48,511,212 | 55.2 kb | Distal (>10kb) Multiome | 268 | |
| chr19:48,513,480–48,514,294 | 58.3 kb | Distal (>10kb) Multiome | 585 | |
| chr19:48,614,318–48,615,255 | 159.3 kb | Distal (>10kb) Multiome | 524 | |
| chr19:48,618,726–48,619,869 | 163.8 kb | Distal (>10kb) Multiome | 1012 | |
| chr19:48,623,839–48,624,688 | 168.7 kb | Distal (>10kb) Multiome | 529 | |
| chr19:48,629,369–48,631,306 | 174.4 kb | Distal (>10kb) Multiome | 402 | |
| chr19:48,634,242–48,636,244 | 179.0 kb | Distal (>10kb) Multiome | 868 | |
| chr19:48,636,802–48,639,603 | 182.1 kb | Distal (>10kb) Multiome | 956 | |
| chr19:48,645,454–48,647,163 | 191.0 kb | Distal (>10kb) Multiome | 750 | |
| chr19:48,675,421–48,675,873 | 220.0 kb | Distal (>10kb) Multiome | 415 | |
| chr19:48,695,830–48,697,033 | 240.5 kb | Distal (>10kb) Multiome | 253 | |
| chr19:48,713,646–48,714,846 | 258.7 kb | Distal (>10kb) Multiome | 719 | |
| chr19:48,716,551–48,717,038 | 261.3 kb | Distal (>10kb) Multiome | 241 | |
| chr19:48,720,420–48,721,301 | 265.3 kb | Distal (>10kb) Multiome | 689 | |
| chr19:48,735,001–48,735,602 | 279.7 kb | Distal (>10kb) Multiome | 161 | |
| chr19:48,738,441–48,739,812 | 283.3 kb | Distal (>10kb) Multiome | 743 | |
| chr19:48,741,194–48,741,939 | 286.1 kb | Distal (>10kb) Multiome | 350 | |
| chr19:48,746,830–48,747,395 | 291.5 kb | Distal (>10kb) Multiome | 402 | |
| chr19:48,752,314–48,753,547 | 297.4 kb | Distal (>10kb) Multiome | 545 |
Genomic view of the KCNJ14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.