The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Alternate splicing results in several transcript variants. [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for KCNC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCNC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCNC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:50,147,523–50,148,432 | 181.2 kb | Distal (>10kb) Multiome | 615 | |
| chr19:50,203,034–50,204,072 | 125.8 kb | Distal (>10kb) Multiome | 363 | |
| chr19:50,205,195–50,205,903 | 124.0 kb | Distal (>10kb) Multiome | 364 | |
| chr19:50,311,942–50,312,908 | 17.1 kb | Distal (>10kb) Multiome | 364 | |
| chr19:50,313,900–50,314,529 | 15.1 kb | Distal (>10kb) Multiome | 114 | |
| chr19:50,315,313–50,316,408 | 13.4 kb | Distal (>10kb) Multiome | 363 | |
| chr19:50,325,322–50,326,594 | 3.6 kb | Proximal (<10kb) Multiome | 748 | |
| chr19:50,328,019–50,330,066 | 37 bp | At TSS Multiome | 699 | |
| chr19:50,330,341–50,331,411 | 1.5 kb | Proximal (<10kb) Multiome | 479 | |
| chr19:50,332,395–50,334,325 | 4.2 kb | Proximal (<10kb) Multiome | 907 | |
| chr19:50,368,630–50,369,092 | 39.6 kb | Distal (>10kb) Multiome | 311 | |
| chr19:50,376,225–50,377,452 | 47.3 kb | Distal (>10kb) Multiome | 931 | |
| chr19:50,383,444–50,384,805 | 54.9 kb | Distal (>10kb) Multiome | 863 | |
| chr19:50,414,638–50,415,204 | 85.6 kb | Distal (>10kb) Multiome | 377 | |
| chr19:50,431,430–50,432,503 | 102.5 kb | Distal (>10kb) Multiome | 530 | |
| chr19:50,475,914–50,477,044 | 147.2 kb | Distal (>10kb) Multiome | 622 | |
| chr19:50,510,707–50,511,948 | 182.0 kb | Distal (>10kb) Multiome | 794 | |
| chr19:50,556,266–50,557,084 | 227.3 kb | Distal (>10kb) Multiome | 463 |
Genomic view of the KCNC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.